3-Chlorophenylacetic acid → N-(3-chlorophenylacetyl)-2-hydroxy-3-bromo-5-chloroaniline

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[OH:12][C:13]1[C:19]([Br:20])=[CH:18][C:17]([Cl:21])=[CH:16][C:14]=1[NH2:15].C(N1C=CN=C1)(N1C=CN=C1)=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([NH:15][C:14]2[CH:16]=[C:17]([Cl:21])[CH:18]=[C:19]([Br:20])[C:13]=2[OH:12])=[O:11])[CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 158793-Chlorophenylacetic acid

HCID 682631,1'-Carbonyldiimidazole

HCID 155210892-Amino-6-bromo-4-chlorophenol

생성물 1

HCID 22618247N-(3-chlorophenylacetyl)-2-hydroxy-3-bromo-5-chloroaniline수율 67.5%

실험 절차

Using the normal amide forming conditions, the condensation of 3-chlorophenylacetic acid (13.54 g, 0.079 mol) and 2-hydroxy-3-bromo-5-chloroaniline (17.7 g, 0.079 mol) with 1,1′-carbonyl diimidazole (13.5 g, 0.083 mol) gave the title compound (20 g).

출처 및 근거

ORD 기록: ord-8cb384c7dedf4082999b9fd54f8ca7c8
출처 데이터셋: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06372770B1

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