Toluene → 1,4-dihydro-3H-2-benzopyran-3-one

HRID 842325

반응식

HRID 842325 반응식
[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2].C(Cl)Cl.[C:10]1(C)[CH:15]=[CH:14]C=[CH:12][CH:11]=1.C(C1C=CC=CC=1)C>O.C1(C)C(C)=CC=CC=1>[CH2:5]1[C:6]2[C:12](=[CH:11][CH:10]=[CH:15][CH:14]=2)[CH2:2][C:1](=[O:3])[O:4]1

참가 물질

7

반응물 4

HCID 1140TolueneHCID 6344DichloromethaneHCID 7500EthylbenzeneHCID 8857Ethyl Acetate

생성물 1

HCID 780921,4-dihydro-3H-2-benzopyran-3-one

시약·촉매·용매 2

HCID 962Water용매HCID 7237O-Xylene용매

실험 절차

Recovery of isochromanones after the reaction is possible by concentration of reaction mixture or extraction with organic solvents such as ethyl acetate, methylene chloride, toluene, xylene, and ethylbenzene. Depending on the target isochromanones, when there are two layers, i.e., water layer and product layer, it is possible to separate the water layer and remove it. In particular, when the product is 3-isochromanone, the product layer is liquid at 85° C. or higher, and the solubility in water is low so that the target compound can be recovered by the operation of separation. Further, it is possible to obtain high purity 3-isochromanone by distillation purification under reduced pressure.

후처리

  1. customto separate the water layer
  2. customremove it
  3. customat 85° C.
  4. customcan be recovered by the operation of separation

출처 및 근거

ORD 기록
ord-08c3f210f5904025865c4c3628dbaab9
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06372921B1

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