Toluene → 1,4-dihydro-3H-2-benzopyran-3-one

HRID 842326

반응식

HRID 842326 반응식
[C:1]([O:4][CH2:5][CH3:6])(=[O:3])[CH3:2].[C:7]1(C)[CH:12]=[CH:11]C=[CH:9][CH:8]=1.C1(C)C(C)=CC=CC=1.C(C1C=CC=CC=1)C>C(Cl)Cl>[CH2:5]1[C:6]2[C:9](=[CH:8][CH:7]=[CH:12][CH:11]=2)[CH2:2][C:1](=[O:3])[O:4]1

참가 물질

6

반응물 4

HCID 1140TolueneHCID 7237O-XyleneHCID 7500EthylbenzeneHCID 8857Ethyl Acetate

생성물 1

HCID 780921,4-dihydro-3H-2-benzopyran-3-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

After the reaction, recovery of isochromanones can be carried out by concentration of reaction mixture or extraction with an organic solvent such as ethyl acetate, toluene, xylene, ethylbenzene, or methylene chloride. When the reaction mixture is separated into two layers, i.e., a water layer and a product layer, depending on the target isochromanones, it is possible to separate and remove the water layer. In particular, when the product is 3-isochromanone, the product layer is liquid at 85° C. or higher, so that solubility in water is low and the target compound can be recovered by separation operation. Further, distillation and purification under reduced pressure can give rise to highly pure 3-isochromanone.

후처리

  1. customWhen the reaction mixture is separated into two layers, i.e.
  2. customto separate
  3. customremove the water layer
  4. customat 85° C.
  5. customthe target compound can be recovered by separation operation
  6. distillationFurther, distillation and purification under reduced pressure

출처 및 근거

ORD 기록
ord-bdf2f6d3faaf446184656218d3c84c1f
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06372921B1

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