HCID 178448467, 화합물 → HCID 178448470, 화합물

HRID 84234

반응식

HRID 84234 반응식
[CH3:1][C@@:2]([S:43]([CH3:46])(=[O:45])=[O:44])([CH2:13][CH2:14][N:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH2:28][C@H:29]3[CH2:34][CH2:33][C@H:32]([O:35]C4CCCCO4)[CH2:31][CH2:30]3)=[CH:23][CH:22]=2)=[CH:17][C:16]1=[O:42])[C:3]([NH:5][O:6]C1CCCCO1)=[O:4].ONC(=O)[C@](C)(S(C)(=O)=O)CCN1C=CC(C2C=CC(OC[C@H]3CC[C@@H](O)CC3)=CC=2)=CC1=O>>[OH:6][NH:5][C:3](=[O:4])[C@:2]([CH3:1])([S:43]([CH3:46])(=[O:45])=[O:44])[CH2:13][CH2:14][N:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH2:28][C@H:29]3[CH2:30][CH2:31][C@H:32]([OH:35])[CH2:33][CH2:34]3)=[CH:23][CH:22]=2)=[CH:17][C:16]1=[O:42]

참가 물질

3

반응물 2

HCID 178448467HCID 178448467, 화합물HCID 178448469HCID 178448469, 화합물

생성물 1

HCID 178448470HCID 178448470, 화합물수율 83.9%

실험 절차

The title compound (300 mg, 83%) was prepared from (2R)-2-methyl-2-(methylsulfonyl)-4-[2-oxo-4-(4-{[trans-4-(tetrahydro-2H-pyran-2-yloxy)cyclohexyl]methoxy}phenyl)pyridin-1(2H)-yl]-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (480 mg, 0.726 mmol) by a procedure analogous to that described for (2R)-N-hydroxy-4-[4-{4-[(cis-4-hydroxycyclohexyl)methoxy]phenyl}-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)butanamide Example 8, Step F. LCMS m/z 493.7 (M+1)H NMR (400 MHz, DMSO-d6) δ ppm 0.92-1.23 (m, 4 H) 1.54 (s, 3 H) 1.58-1.72 (m, 1 H) 1.81 (br. s., 4 H) 2.06-2.21 (m, 1 H) 2.41 (s, 1 H) 3.08 (s, 3 H) 3.25-3.41 (m, 1 H) 3.74 (br. s., 1 H) 3.80 (d, J=6.44 Hz, 2 H) 3.98-4.17 (m, 1 H) 6.48-6.71 (m, 2 H) 6.85-7.06 (m, 2 H) 7.52-7.78 (m, 3 H) 11.15 (s, 1 H)

출처 및 근거

ORD 기록
ord-7c995525808b4dcdb644ac96896f70d0
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846933B2

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