Sodium Bicarbonate → Butylamide tetrasodium salt

HRID 842351노트

반응식

HRID 842351 반응식
[CH2:1]([NH-:5])[CH2:2][CH2:3][CH3:4].C(=O)(O)[O-].[Na+:10]>O1CCOCC1>[Na+:10].[Na+:10].[Na+:10].[Na+:10].[CH2:1]([NH-:5])[CH2:2][CH2:3][CH3:4].[CH2:1]([NH-:5])[CH2:2][CH2:3][CH3:4].[CH2:1]([NH-:5])[CH2:2][CH2:3][CH3:4].[CH2:1]([NH-:5])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 516892Sodium BicarbonateHCID 22027117Butylamide

생성물 1

HCID 86757957Butylamide tetrasodium salt

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

Subsequently, to the above butylamide of S1 anhydride (160 mg) were added a sodium bicarbonate aqueous solution (NaHCOs 121 mg, water 20 mL) and 1,4-dioxane (20 mL), and the resultant was allowed to undergo a reaction at room temperature for 16 hours. After the reaction was completed, the solvent was removed under reduced pressure to afford butylamide tetrasodium salt of S1 compound (200 mg). The 1H-NMR and IR data of this compound were as shown below. From these data, the compound thus obtained was confirmed to be a derivative in which the carboxyl groups bonded to the saturated carbon atoms in the structural formula of S1 compound were butylamidated, while other carboxyl groups were substituted with sodium salt.

후처리

  1. customa reaction at room temperature for 16 hours
  2. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-9729af8d6dbf4140bf1b35289c31c8d7
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06372943B1

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