Dichlorodimethylsilane → 4-(3,5-Dimethylphenyl)-2-isopropylindene

HRID 842520노트

반응식

HRID 842520 반응식
[Si](Cl)(Cl)(C)C.[CH3:6][C:7]1[CH:8]=[C:9]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[C:17]([CH:23]([CH3:25])[CH3:24])[CH-:18]3)[CH:10]=[C:11]([CH3:13])[CH:12]=1.[Li+]>C1COCC1>[CH3:13][C:11]1[CH:10]=[C:9]([C:14]2[CH:22]=[CH:21][CH:20]=[C:19]3[C:15]=2[CH:16]=[C:17]([CH:23]([CH3:25])[CH3:24])[CH2:18]3)[CH:8]=[C:7]([CH3:6])[CH:12]=1

참가 물질

4

반응물 2

HCID 6398DichlorodimethylsilaneHCID 22023013Lithium 4-(3,5-dimethylphenyl)-2-isopropylindenide

생성물 1

HCID 220230144-(3,5-Dimethylphenyl)-2-isopropylindene수율 72.8%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

SiMe2Cl2 (0.69 g, 5.4 mmol) was dissolved in 80 mL of THF. While stirring, lithium 4-(3′,5′-dimethylphenyl)-2-iso-propylindenide (2.9 g, 11 mmol) was added as a dry powder and the contents allowed to stir overnight at room temperature. The solvent was removed in vacuo and the residue was taken up in pentane and filtered to removed LiCl salts. The pentane was removed in vacuo to yield a flaky white solid (2.1 g, 67%)

후처리

  1. stirringto stir overnight at room temperature
  2. customThe solvent was removed in vacuo
  3. filtrationfiltered
  4. customto removed LiCl salts
  5. customThe pentane was removed in vacuo

출처 및 근거

ORD 기록
ord-ab485e3a6a934fd9aaa3cd1087fb5365
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376410B1

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