1H-Indene, 2-(1-methylethyl)-4-phenyl- → Lithium 2-isopropyl-4-phenylindenide

HRID 842583노트

반응식

HRID 842583 반응식
[CH:1]([C:4]1[CH2:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:9]=[CH:8][CH:7]=2)([CH3:3])[CH3:2].C([Li:23])CCC>C1(C)C=CC=CC=1>[CH:1]([C:4]1[CH-:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:9]=[CH:8][CH:7]=2)([CH3:3])[CH3:2].[Li+:23]

참가 물질

4

반응물 2

HCID 180082381H-Indene, 2-(1-methylethyl)-4-phenyl-HCID 178418339Butyllithium

생성물 1

HCID 22023052Lithium 2-isopropyl-4-phenylindenide수율 93.5%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a toluene solution (25 ml) of 2-isopropyl-4-phenylindene (3.34 g, 14.25 mmol), in a glovebox filled with argon, was added n-butyl lithium(5.500 ml, 13.75 mmol). The mixture was stirred at room temperature overnight. The toluene was removed under reduced pressure. Hexane (20 ml) was added and removed under reduced pressure then added again (50 ml). The mixture was stirred for 1 h then filtered, washed with about 15 ml hexane and the filtrate dried under vacuum. The lithium indenide product (3.09 g) was obtained as an orange-brown powder. This material was stored in the glovebox until needed.

후처리

  1. customThe toluene was removed under reduced pressure
  2. additionHexane (20 ml) was added
  3. customremoved under reduced pressure
  4. additionthen added again (50 ml)
  5. stirringThe mixture was stirred for 1 h
  6. filtrationthen filtered
  7. washwashed with about 15 ml hexane
  8. customthe filtrate dried under vacuum

출처 및 근거

ORD 기록
ord-2ff05cc76c4b4a459cb3b81d4d9c1339
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376406B1

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