Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrazine hydrate (1:1) → 2-Methoxycarbonylpyridine-5-carboxylic acid hydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 2-Ethoxy-1-(ethoxycarbonyl)-1,2-dihydroquinoline | HCID 27833 | — |
| 반응물 | 6-(Methoxycarbonyl)pyridine-3-carboxylic acid | HCID 579631 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Methoxycarbonylpyridine-5-carboxylic acid hydrazide | HCID 18726776 | 81.3% |
반응 단계
A mixture of 2-methoxycarbonylpyridine-5-carboxylic acid (Chem. Abstr., 68, 68840 h (1968)) (0.40 g, 2.2 mmol) and N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (0.60 g, 2.4 mmol) in dichloromethane (10 mL) was stirred at room temperature under nitrogen for 0.75 hour. Hydrazine hydrate (0.110 mL, 2.2 mmol) was then added and after a further 5 minutes the precipitate formed was collected by filtration, washed with dichloromethane and dried to give the title compound (0.349 g, 81%) as white solid, mp 177-180° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06376490B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-095a2015d53c470ea27d57d4dcc1e1c0 |
| 출처 메모 | uspto-grants-2002_04 |