Nitric Acid → HCID 22614896, 화합물

HRID 842701노트

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[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[C:7]([O:13][CH3:14])[C:6]([O:15][CH3:16])=[N:5]2.[N+:17]([O-])([OH:19])=[O:18]>>[Cl:12][C:11]1[C:10]([N+:17]([O-:19])=[O:18])=[C:9]2[C:4](=[CH:3][C:2]=1[Cl:1])[N:5]=[C:6]([O:15][CH3:16])[C:7]([O:13][CH3:14])=[N:8]2

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 120471106,7-Dichloro-2,3-dimethoxyquinoxaline

생성물 1

HCID 22614896HCID 22614896, 화합물수율 92%

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온도: 10 °C

실험 절차

6,7-Dichloro-2,3-dimethoxyquinoxaline (25 g, 0.096 mol) was added, portionwise, to fuming nitric acid (0.113 L) which had been pre-cooled to −5° C. The solution was allowed to warm to 10° C. and stirring continued for 2 hours. The solution was then poured into an ice/water mixture (0.5 L). The slurry was filtered and the solid was washed with water and isopropanol (0.05 L) to give 6,7-dichloro-2,3-dimethoxy-5-nitroquinoxaline(27 g, 92%) as a beige solid. m.p. 184-186° C.

후처리

filtrationThe slurry was filtered
washthe solid was washed with water and isopropanol (0.05 L)

출처 및 근거

ORD 기록: ord-05f217c4140c4387bd8ccb75f92ac97a
출처 데이터셋: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06376490B1

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