Benzoyl Peroxide → HCID 22615271, 화합물

HRID 842708

반응식

HRID 842708 반응식
C1C(=O)N([Cl:8])C(=O)C1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Cl:27][C:28]1[C:33]([C:34]#[N:35])=[CH:32][CH:31]=[C:30]([CH3:36])[N:29]=1>C1C=CC=CC=1>[Cl:27][C:28]1[C:33]([C:34]#[N:35])=[CH:32][CH:31]=[C:30]([CH2:36][Cl:8])[N:29]=1

참가 물질

5

반응물 3

HCID 7187Benzoyl PeroxideHCID 31398ChlorosuccinimideHCID 5204002-Chloro-6-methylpyridine-3-carbonitrile

생성물 1

HCID 22615271HCID 22615271, 화합물

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

NCS (1.44 g, 10.8 mmol) and benzoyl peroxide (238 mg, 0.98 mmol) were added to a stirred solution of 2-chloro-3-cyano-6-methyl-pyridine (750 mg, 4.92 mmol) in benzene (35 mL) and the mixture was heated to reflux. After 4 h, the mixture was cooled and filtered. The filtrate was diluted with ethyl acetate and was washed with sodium metabisulfite solution, water and brine, dried (Na2SO4) and evaporated in vacuo. The residue was purified by chromatography on silica (chloroform) to give the title compound:

후처리

  1. temperaturethe mixture was heated to reflux
  2. temperaturethe mixture was cooled
  3. filtrationfiltered
  4. additionThe filtrate was diluted with ethyl acetate
  5. washwas washed with sodium metabisulfite solution, water and brine
  6. dry with materialdried (Na2SO4)
  7. customevaporated in vacuo
  8. customThe residue was purified by chromatography on silica (chloroform)

출처 및 근거

ORD 기록
ord-770e2c5221a6477481db72971c6ebf26
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376499B1

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