Thionyl Chloride → alpha-(3-Chloromethylphenoxy)acetonitrile
반응식
O[CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[O:6][CH2:7][C:8]#[N:9].S(Cl)([Cl:15])=O>C(OCC)C.CN(C)C=O>[Cl:15][CH2:2][C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][CH:12]=1)[O:6][CH2:7][C:8]#[N:9]참가 물질
5
실험 절차
α-(3-Hydroxymethylphenoxy)acetonitrile (0.055 mol) in diethylether (150 ml) is stirred with thionyl chloride (0.060 mol) and a few drops of dimethylformamide at 40° C. for 1 hr. the solution is washed with water and brine, then evaporated to give α-(3-chloromethylphenoxy)acetonitrile as a yellow oil which is used directly in the next step.
후처리
- washthe solution is washed with water and brine
- customevaporated
출처 및 근거
- ORD 기록
- ord-3e5b4d328bba4c59808f4f787cf802b7
- 출처 데이터셋
- uspto-grants-2002_04
- 특허 번호
- US06376512B1
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