Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,3,4-Trifluoroaniline | HCID 77468 | — |
| 반응물 | Methyl (2R)-2-[(methylsulfonyl)oxy]propanoate | HCID 57320743 | — |
| 촉매 | Tetrahexylammonium chloride | HCID 80021 | — |
| 생성물 | Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate | HCID 10125210 | — |
반응 단계
In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-2-[(methanesulfonyl)oxy]propionate (78 mg) and tetrahexylammonium chloride (40 mg) to give the title compound as an oily substance. As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 38 mg (24%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087778B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-d9b0bffd894b426d850fcbbf6660c959 |
| 출처 메모 | uspto-grants-2006_08 |