tert-Butyl chloroacetate → Tert-butyl 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-acetate

HRID 842994

반응식

ClC1C=CC(N2CCN(S(N)(=O)=O)CC2)=CC=1.Cl[CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21].[C:27]1([C:41]2[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=2)[CH:32]=[CH:31][C:30]([CH2:33][N:34]2[S:38](=[O:40])(=[O:39])[NH:37][CH2:36][CH2:35]2)=[CH:29][CH:28]=1>>[C:27]1([C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH:28]=[CH:29][C:30]([CH2:33][N:34]2[S:38](=[O:40])(=[O:39])[N:37]([CH2:19][C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:36][CH2:35]2)=[CH:31][CH:32]=1

참가 물질

반응물 3

HCID 66052tert-Butyl chloroacetate

HCID 226156705-(Biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine

HCID 22615685[4-(4-Chlorophenyl)piperazine-1-sulfonyl]amine

생성물 1

HCID 54373566Tert-butyl 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-acetate

실험 절차

Proceeding as described in Example 7, Step 2 above, but substituting potassium tert-butoxide and [4-(4-chlorophenyl)piperazine-1-sulfonyl]amine with tert-butyl chloroacetate and 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine gave tert-butyl 5-(biphenyl-4-ylmethyl)-1,1-dioxo-1,2,5-thiadiazolidine-2-acetate.

출처 및 근거

ORD 기록: ord-2a46e7bf62a247fb993106485e878c4f
출처 데이터셋: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06376506B1

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