Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Fluorophenyl)hydrazine → 5-Amino-4-(3-iodobenzoyl)-1-(4-fluorophenyl)pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Fluorophenyl)hydrazine | HCID 69982 | — |
| 반응물 | 2-(3-Iodobenzoyl)-3-phenylaminoacrylonitrile | HCID 67024274 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Hexane | HCID 8058 | — |
| 생성물 | 5-Amino-4-(3-iodobenzoyl)-1-(4-fluorophenyl)pyrazole | HCID 9866075 | 87.4% |
반응 단계
A mixture of 4-fluorophenylhydrazine (26.6 g, 211 mmol) and 2-(3-iodobenzoyl)-3-phenylaminoacrylonitrile (79 g, 211 mmol) in ethanol (400 ml) was heated at reflux under a nitrogen atmosphere. After 30 minutes, the reaction mixture was cooled to room temperature, diluted with hexane to give 5-amino-4-(3-iodobenzoyl)-1-(4-fluorophenyl)pyrazole (75.1 g) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06376527B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-7cfb53d0f0e04ec5816ef1a8f3571987 |
| 출처 메모 | uspto-grants-2002_04 |