Isopropylamine → 2-Methylpropanoic acid (carboxymethylphosphonomethyl carbamoyloxy)-methyl ester-isopropylamine salt

HRID 843095노트

반응식

HRID 843095 반응식
[C:1]([CH2:4][O:5][P:6]([CH2:9][NH:10][C:11]([O:13][CH2:14][O:15][C:16](=[O:20])[CH:17]([CH3:19])[CH3:18])=[O:12])([OH:8])=[O:7])([OH:3])=[O:2].[CH:21]([NH2:24])([CH3:23])[CH3:22]>CC(C)=O>[CH:21]([NH2:24])([CH3:23])[CH3:22].[C:1]([CH2:4][O:5][P:6]([CH2:9][NH:10][C:11]([O:13][CH2:14][O:15][C:16](=[O:20])[CH:17]([CH3:18])[CH3:19])=[O:12])([OH:8])=[O:7])([OH:3])=[O:2]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 867579662-Methylpropanoic acid (carboxymethylphosphonomethylcarbamoyloxy)-methyl ester

생성물 1

HCID 867579682-Methylpropanoic acid (carboxymethylphosphonomethyl carbamoyloxy)-methyl ester-isopropylamine salt수율 90.8%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a stirred ice cold solution of 2-methylpropanoic acid (carboxymethylphosphonomethylcarbamoyloxy)-methyl ester (14.1 g, 43.8 mmol) in 80 mL of acetone was added isopropylamine (3.71 mL, 43.8 mmol). After 15 min of stirring the solvent was removed was removed under vacuum. The solid was washed with diethyl ether and subsequently dried under vacuum to afford 14.8 g of a tannish solid. 1H-NMR (300 MHz, D2O) δ (ppm): 1.01 (dd, 6H), 1.16 (d, 6H), 2.51 (m, 1H), 3.35 (m, 1H), 3.47 (d, 2H), 4.09 (d, 2H), 5.63 (d, 2H).

후처리

  1. customwas removed
  2. customwas removed under vacuum
  3. washThe solid was washed with diethyl ether
  4. customsubsequently dried under vacuum

출처 및 근거

ORD 기록
ord-e55d0862b0784cba84138ed9f8ca2ffb
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376548B1

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