Sulfuric Acid → 2,2,3,4,4,4-Hexafluorobutyric acid

HRID 843368노트

반응식

HRID 843368 반응식
[F:1][C:2]([F:11])([CH:5]([F:10])[C:6]([F:9])([F:8])[F:7])[CH2:3][OH:4].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=[O:13].[K+].[K+].S(=O)(=O)(O)O>O>[F:1][C:2]([F:11])([CH:5]([F:10])[C:6]([F:9])([F:7])[F:8])[C:3]([OH:13])=[O:4]

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 24502Potassium DichromateHCID 5339902,2,3,4,4,4-Hexafluorobutan-1-ol

생성물 1

HCID 226171612,2,3,4,4,4-Hexafluorobutyric acid수율 91.8%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
100 °C

실험 절차

First, 9.1 g (50 mmol) of 2,2,3,4,4,4-hexafluorobutan-1-ol was dissolved in 40 ml of water, to which 14.7 g (50 mmol) of potassium dichromate and 17 ml of concentrated sulfuric acid, and the mixture was heated at 100° C. for 3 hours. After cooling, the reaction mixture was extracted with diethyl ether. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to give 9.0 g of 2,2,3,4,4,4-hexafluorobutyric acid.

후처리

  1. temperatureAfter cooling
  2. extractionthe reaction mixture was extracted with diethyl ether
  3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-7dd410fa401a49dba6d450d19267e1cd
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376710B2

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