Tributylstannane → Bis[1-(2-hydroxyethoxy)-2,2,6,6-tetramethylpiperidin-4-yl]Sebacate

HRID 843473

반응식

HRID 843473 반응식
C([SnH](CCCC)CCCC)CCC.I[CH2:15][CH2:16][OH:17].[C:18]([O:42][CH:43]1[CH2:48][C:47]([CH3:50])([CH3:49])[N:46]([OH:51])[C:45]([CH3:53])([CH3:52])[CH2:44]1)(=[O:41])[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][C:27]([O:29][CH:30]1[CH2:35][C:34]([CH3:37])([CH3:36])[N:33]([OH:38])[C:32]([CH3:40])([CH3:39])[CH2:31]1)=[O:28].CCCCCCC.CCCCCCC.[C:68](OCC)(=[O:70])[CH3:69]>ClC1C=CC=CC=1>[OH:17][CH2:16][CH2:15][O:38][N:33]1[C:32]([CH3:39])([CH3:40])[CH2:31][CH:30]([O:29][C:27](=[O:28])[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][C:18]([O:42][CH:43]2[CH2:44][C:45]([CH3:53])([CH3:52])[N:46]([O:51][CH2:69][CH2:68][OH:70])[C:47]([CH3:50])([CH3:49])[CH2:48]2)=[O:41])[CH2:35][C:34]1([CH3:36])[CH3:37]

참가 물질

7

반응물 5

HCID 5948TributylstannaneHCID 8900HeptaneHCID 12225IodoethanolHCID 11272241Bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)decandioateHCID 21899848Ethylacetate heptane

생성물 1

HCID 22507665Bis[1-(2-hydroxyethoxy)-2,2,6,6-tetramethylpiperidin-4-yl]Sebacate

시약·촉매·용매 1

HCID 7964Chlorobenzene용매

실험 절차

Tributyltin hydride is added dropwise to a solution of 2-iodoethanol and excess bis(1-oxyl-2,2,6,6-tetramethylpiperidin-4-yl) sebacate in chlorobenzene. The crude reaction mixture is passed through silica gel with heptane and then heptane/ethyl acetate to afford the title compound.

후처리

  1. customThe crude reaction mixture

출처 및 근거

ORD 기록
ord-aa8c911360a94de786f04d0297be498d
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06376584B1

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