Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Boron trifluoride → HCID 18731514, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Boron trifluoride | HCID 6356 | — |
| 반응물 | beta-D-Ribofuranose, 1-acetate 2,3,5-tribenzoate | HCID 81455 | — |
| 반응물 | 5-Hydroxy-1-tetralone | HCID 119921 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 18731514 | HCID 18731514 | 139.5% |
반응 단계
A solution of 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (426 mg, 0.84 mmol), 5-hydroxy-1-tetralone (122 mg, 0.75 mmol) and boron trifluoride diethyletherate (120 mg, 0.84 mmol, 106 μl) in dichloromethane (4 ml) was stirred at room temperature, under argon for 19 hours. Work-up as for Stage 1 in Example 1 then flash chromatography on silica gel (eluting with 2% acetone in toluene) gave the title compound as a colourless oil (308 mg of approx. 51% purity).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06379911B2 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-9bc91ba1127d4f1dbbb67554e2a18d1b |
| 출처 메모 | uspto-grants-2002_04 |