Water → 5-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole

HRID 84358

반응식

HRID 84358 반응식
[CH3:1][N:2]1[C:6]([CH:7]=[O:8])=[CH:5][N:4]=[CH:3]1.[CH2:9](O)[CH2:10][CH2:11][OH:12].CC1(C)C2(CS(O)(=O)=O)C(CC1CC2)=O.O>C1(C)C=CC=CC=1.C(Cl)Cl>[O:8]1[CH2:9][CH2:10][CH2:11][O:12][CH:7]1[C:6]1[N:2]([CH3:1])[CH:3]=[N:4][CH:5]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 104421,3-PropanediolHCID 18462Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)-HCID 5735921-methyl-1H-imidazole-5-carbaldehyde

생성물 1

HCID 579196325-(1,3-Dioxan-2-yl)-1-methyl-1H-imidazole

시약·촉매·용매 2

HCID 1140Toluene용매HCID 6344Dichloromethane용매

실험 절차

To a solution of 1-methyl-1H-imidazole-5-carbaldehyde (2.9 g, 26.3 mmol) in toluene (20 mL) was added propane-1,3-diol (4.01 g, 52.7 mmol) and CSA (0.306 g, 1.317 mmol) and the reaction mixture was heated to reflux with azeotropic removal of the evolved water for 24 hours. The reaction mixture was cooled to RT, diluted with DCM and washed with NaHCO3 solution.

후처리

  1. temperaturethe reaction mixture was heated
  2. washwashed with NaHCO3 solution

출처 및 근거

ORD 기록
ord-e7428bd3e70b498dbb8013ec465cb6e1
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846927B2

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