Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Glycinamide → 2-[[4-(4-Cyanoanilino)-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Glycinamide | HCID 69020 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-[[4-Chloro-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]benzonitrile | HCID 486423 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | 2-[[4-(4-Cyanoanilino)-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]amino]acetamide | HCID 505409 | 41.4% |
반응 단계
Intermediate (27) (0.00423 mol), 2-amino-acetamide (0.00431 mol), 1,4-dioxane (20 ml) and N,N-diisopropylethylamine (0.00862 mol) were combined and stirred at RT for 16 hours under argon. The reaction mixture was quenched with H2O and filtered. The residue was washed with H2), filtered and recrystallized from ACN (200 ml). The precipitate was filtered off and dried, yielding 0.75 g (41.4%) of [N-[4-[(4-cyanophenyl)amino]-6-[(2,6-dichlorophenyl)methyl]-1,3,5-triazin-2-yl]]aminoacetamide (compound 14).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06380194B1 |
| 출처 데이터셋 | uspto-grants-2002_04 |
| ORD ID | ord-c5e37fc441da497896a65bf17f3eeced |
| 출처 메모 | uspto-grants-2002_04 |