Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyruvic Acid → 2-(2,3,4-Trifluoroanilino)propionic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyruvic Acid | HCID 1060 | — |
| 반응물 | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(2,3,4-Trifluoroanilino)propionic acid | HCID 22015866 | 98.1% |
반응 단계
2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in isopropanol (IPA; 40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under atmospheric pressure in a hydrogen atmosphere for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.11 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087778B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-d2ae1fef10194c6597c1745779551014 |
| 출처 메모 | uspto-grants-2006_08 |