참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyruvic Acid | HCID 1060 | — |
| 반응물 | 1,2,3-Trifluoro-4-nitrobenzene | HCID 69871 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-(2,3,4-Trifluoroanilino)propionic acid | HCID 22015866 | 97.8% |
반응 단계
2,3,4-Trifluoronitrobenzene (5.03 g) and pyruvic acid (2.75 g) were dissolved in IPA (40 ml). After adding 10% Pd—C (0.21 g), the mixture was stirred at 40° C. under a hydrogen gas pressure of 2.94 MPa for 3 hours. After filtering off Pd—C, the obtained filtrate was concentrated under reduced pressure. Thus the title compound (6.09 g) was obtained as colorless crystals. Various spectral data of this product was identical with those of a specimen synthesized separately.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07087778B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-000aaf21ce6b430c92135e59c6c72ea3 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
