Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 4-bromobutyrate → Ethyl 4-phenoxybutanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 4-bromobutyrate | HCID 76300 | — |
| 반응물 | 2,3,4,5-Tetrahydro-1-benzoxepin-5-one | HCID 315575 | — |
| 생성물 | Ethyl 4-phenoxybutanoate | HCID 222539 | — |
반응 단계
Scheme 1 shows a general method for preparation of 3,4-dihydrobenzo[b]oxepin-5(2H)-one intermediates 66 by O-alkylation of a phenolic compound with ethyl 4-bromobutanoate to give a ethyl 4-phenoxybutanoate intermediate 67, followed by saponification to the carboxylic acid 68 and intramolecular cyclization under acidic conditions.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846762B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-3f79208ddd564cc696278045e61effac |
| 출처 메모 | uspto-grants-2014_09 |