2-(4-Nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid → 2H-Isoindole-2-acetic acid, 4-amino-alpha-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-

HRID 844221

반응식

HRID 844221 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:23])[N:7]([CH:14]([CH2:18][CH2:19][C:20](=[O:22])[NH2:21])[C:15]([OH:17])=[O:16])[C:8]2=[O:13])([O-])=O.[H][H]>CN(C)C=O.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[C:6](=[O:23])[N:7]([CH:14]([CH2:18][CH2:19][C:20](=[O:22])[NH2:21])[C:15]([OH:17])=[O:16])[C:8]2=[O:13]

참가 물질

5

반응물 2

HCID 155498382-(4-Nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 155498392H-Isoindole-2-acetic acid, 4-amino-alpha-(3-amino-3-oxopropyl)-1,3-dihydro-1,3-dioxo-

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2-(4-nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid (5 mmol) and 10% Pd/C (250 mg) in dimethylformamide is hydrogenated under 60 psi of hydrogen in a Parr Type Shaker to afford 2-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.

출처 및 근거

ORD 기록
ord-99ae6b197ac642b6899a5674131adc78
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06380239B1

연결된 노트

불러오는 중…