Oxalyl chloride → 2-(6-Methoxynaphthalen-2-yl)propanoyl chloride

HRID 844513노트

반응식

HRID 844513 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14](O)=[O:15])[CH:7]=[CH:6]2.C(Cl)(=O)C([Cl:21])=O>CN(C=O)C.C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C@H:13]([CH3:17])[C:14]([Cl:21])=[O:15])[CH:7]=[CH:6]2

참가 물질

5

반응물 2

HCID 65578Oxalyl chlorideHCID 156391Naproxen

생성물 1

HCID 54916922-(6-Methoxynaphthalen-2-yl)propanoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of (S)-6-methoxy-α-methyl-2-naphthaleneacetic acid (23.09 g) and THF (41 mL) is agitated until dissolution is achieved. Oxalyl chloride (17.5 mL) is added to the flask followed by DMF (3 drops) and heptanes (50 mL). The mixture is stirred for approximately 2 hours. The resulting slurry is filtered, washed with heptane (15 mL) and aspirated for 3 minutes and vacuum dried to give 17.44 g.

후처리

  1. stirringThe mixture is stirred for approximately 2 hours
  2. filtrationThe resulting slurry is filtered
  3. washwashed with heptane (15 mL)
  4. customvacuum dried
  5. customto give 17.44 g

출처 및 근거

ORD 기록
ord-1b9ecbecac02427fbba42a1a7b4a338d
출처 데이터셋
uspto-grants-2002_04
특허 번호
US06380388B1

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