Ethyl bromoacetate → Ethyl 4-(2-chloro-4-trifluoromethylphenoxy)phenoxyacetate

HRID 844918

반응식

HRID 844918 반응식
[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.Br[CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23].C(=O)([O-])[O-].[K+].[K+]>C(C(C)=O)C>[Cl:1][C:2]1[CH:15]=[C:14]([C:16]([F:18])([F:17])[F:19])[CH:13]=[CH:12][C:3]=1[O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23])=[CH:9][CH:10]=1

참가 물질

5

반응물 3

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 129406134-[2-Chloro-4-(trifluoromethyl)phenoxy]phenol

생성물 1

HCID 14030465Ethyl 4-(2-chloro-4-trifluoromethylphenoxy)phenoxyacetate

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

1.44 parts of 4-(2-chloro-4-trifluoromethylphenoxy)phenol, 0.84 part of ethyl bromoacetate, and 1.38 parts of anhydrous potassium carbonate were refluxed for 3 hours in 20 parts by volume of methyl ethyl ketone in an atmosphere of nitrogen. After the reaction, the reaction mixture was filtered. The filtrate was concentrated, and water was added. The mixture was then extracted with ethyl acetate. The extract was washed with a 1N aqueous solution of sodium hydroxide and then with water, and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give 1.5 parts of ethyl 4-(2-chloro-4-trifluoromethylphenoxy)phenoxyacetate.

후처리

  1. customAfter the reaction
  2. filtrationthe reaction mixture was filtered
  3. concentrationThe filtrate was concentrated
  4. additionwater was added
  5. extractionThe mixture was then extracted with ethyl acetate
  6. washThe extract was washed with a 1N aqueous solution of sodium hydroxide
  7. dry with materialwith water, and dried over anhydrous sodium sulfate
  8. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-e3007bbb3cd54100847a3d72bab26558
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04755209

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