Thiophene-3-carboxylic acid → 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dipropyl-8-(3-thienyl)-

반응식

[S:1]1[CH:5]=[CH:4][C:3]([C:6](O)=O)=[CH:2]1.[NH2:9][C:10]1[C:11](=[O:24])[N:12]([CH2:21][CH2:22][CH3:23])[C:13](=[O:20])[N:14]([CH2:17][CH2:18][CH3:19])[C:15]=1[NH2:16]>>[CH2:21]([N:12]1[C:11](=[O:24])[C:10]2[NH:9][C:6]([C:3]3[CH:4]=[CH:5][S:1][CH:2]=3)=[N:16][C:15]=2[N:14]([CH2:17][CH2:18][CH3:19])[C:13]1=[O:20])[CH2:22][CH3:23]

참가 물질

반응물 2

HCID 6918Thiophene-3-carboxylic acid

HCID 50986055,6-Diamino-1,3-dipropyl-2,4(1H,3H)-pyrimidinedione

생성물 1

HCID 99050821H-Purine-2,6-dione, 3,7-dihydro-1,3-dipropyl-8-(3-thienyl)-

실험 절차

The starting 1,3-dipropyl-8-(3-thienyl)xanthine is prepared in a manner analogous to that described in Example 2 hereinafter using 3-thiophenecarboxylic acid and 5,6-diamino-1,3-dipropyluracil, mp>250° C.

출처 및 근거

ORD 기록: ord-7ce888016d45424b81c8b05195ddb6b5
출처 데이터셋: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04755517

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