6-Chloropurine riboside → HCID 15611205, 화합물

HRID 845123노트

반응식

HRID 845123 반응식
[C:1]1([C:7]2([CH2:13][NH2:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:15]1[N:20]=[C:19](Cl)[C:18]2[N:22]=[CH:23][N:24]([C@@H:25]3[O:29][C@H:28]([CH2:30][OH:31])[C@@H:27]([OH:32])[C@H:26]3[OH:33])[C:17]=2[N:16]=1>>[C:1]1([C:7]2([CH2:13][NH:14][C:19]3[C:18]4[N:22]=[CH:23][N:24]([C:17]=4[N:16]=[CH:15][N:20]=3)[C@@H:25]3[O:29][C@H:28]([CH2:30][OH:31])[C@@H:27]([OH:32])[C@H:26]3[OH:33])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

3

반응물 2

HCID 930036-Chloropurine ribosideHCID 205110Cyclohexanemethylamine, 1-phenyl-

생성물 1

HCID 15611205HCID 15611205, 화합물수율 42.4%

실험 절차

(1-Phenylcyclohexyl)methylamine (1.80 g, 8 mmol) as prepared below, and 6-chloropurine riboside (2.36 g, 8 mmol) are reacted as described in Example 1. The solvent is removed under reduced pressure, and the residue dissolved up in CHCl3 and washed with water and dried (MgSO4). The solvent is removed under reduced pressure and the residual white foam is purified on silica gel chromatography eluting with 10% MeOH in CH2Cl2 to give N6-((1-phenylcyclohexyl)methyl)adenosine (1.49 g, 42%) as a white glass m.p. 87°-9° C. Found: C, 62.22; H, 6.96; N, 15.70%. C23H29N5O4 calculated requires: C, 62.87; H, 6.61; N, 15.95%.

후처리

  1. customare reacted
  2. customThe solvent is removed under reduced pressure
  3. dissolutionthe residue dissolved up in CHCl3
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. customThe solvent is removed under reduced pressure
  7. customthe residual white foam is purified on silica gel chromatography
  8. washeluting with 10% MeOH in CH2Cl2

출처 및 근거

ORD 기록
ord-652a1ccacd814f8b86b6ed43fbedd285
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04755594

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