HCID 54347464, 화합물 → HCID 53945839, 화합물

HRID 845241노트

반응식

HRID 845241 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH:20]=[CH:21][N+:22]([O-])=O)[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2]>C(O)C.[H][H].S(=O)(=O)(O)O.[C].[Pd]>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH2:20][CH2:21][NH2:22])[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2]

참가 물질

6

반응물 1

HCID 54347464HCID 54347464, 화합물

생성물 1

HCID 53945839HCID 53945839, 화합물수율 65.6%

시약·촉매·용매 4

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매2회HCID 1118Sulfuric Acid용매HCID 178418361HCID 178418361, 화합물용매

실험 절차

5-(2-Nitrovinyl)-4-methyl-beta-carboline-3-carboxylic acid ethyl ester (1 g) is dissolved in ethanol (20 ml) and in a hydrogen atmosphere with stirring is slowly added drop by drop to a suspension of 10% palladium carbon (0.25 g) in ethanol (50 ml) and sulfuric acid (0.1 ml). In the end, it is stirred for another half hour more. Then the catalyst is suctioned off and the filtrate evaporated. After the usual working up, 0.6 g of the title compound is obtained.

후처리

  1. stirringIn the end, it is stirred for another half hour more
  2. customthe filtrate evaporated

출처 및 근거

ORD 기록
ord-b03012d65ea24999b03ece087b709ede
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04757070

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