Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromine → 4-Bromo-3,4-dihydro-1-benzoxepin-5(2H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 2,3,4,5-Tetrahydro-1-benzoxepin-5-one | HCID 315575 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Bromo-3,4-dihydro-1-benzoxepin-5(2H)-one | HCID 13863234 | — |
반응 단계
To a solution of 3,4-dihydro-2H-benzo[b]oxepin-5-one (3.10 g, 12.8 mmol) in diethyl ether at 0° C., bromine (625 μl, 12.2 mmol) was added and stirred for 2.5 hours, gradually raising the temperature to room temperature. Purification on silica and triturating using diethyl ether and hexanes gave 4-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846762B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-2c48424fc66e4bfbbf7a255b7d0ce46f |
| 출처 메모 | uspto-grants-2014_09 |