Butyl 3-furyl(hydroxy)acetate → Butyl 2-(fur-3-yl)-2-oxo-acetate

HRID 845253노트

반응식

HRID 845253 반응식
[O:1]1[CH:5]=[CH:4][C:3]([CH:6]([OH:14])[C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:8])=[CH:2]1.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4]>C1C=CC=CC=1>[O:1]1[CH:5]=[CH:4][C:3]([C:6](=[O:14])[C:7]([O:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:8])=[CH:2]1

참가 물질

4

반응물 2

HCID 12335665Butyl 3-furyl(hydroxy)acetateHCID 178418268HCID 178418268, 화합물

생성물 1

HCID 13986137Butyl 2-(fur-3-yl)-2-oxo-acetate수율 83.4%

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

A mixture of 39.6 g of butyl fur-3-yl-glycolate and 8.6 g of lead tetraacetate in 400 ml of absolute benzene is refluxed for 8 hours. After cooling to room temperature, the salts are filtered off and washed with benzene, and the combined benzene phases are shaken with a 10% strength sodium bicarbonate solution and a saturated sodium chloride solution. After drying over sodium sulphate, filtering off and concentrating, the oily residue is distilled in vacuo. 32.7 g (83%) of an oil, boiling point 80° C. (0.3 Torr), nD20 =1.477, are obtained.

후처리

  1. temperatureis refluxed for 8 hours
  2. filtrationthe salts are filtered off
  3. washwashed with benzene
  4. dry with materialAfter drying over sodium sulphate
  5. filtrationfiltering off
  6. concentrationconcentrating
  7. distillationthe oily residue is distilled in vacuo

출처 및 근거

ORD 기록
ord-56a45a5dfd974825b9f1604ecb08b06a
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04757085

반응 노트

불러오는 중…