Hydroquinone → Methyl acrylamidoglycolate methyl ether

HRID 845874노트

반응식

HRID 845874 반응식
[C:1]([NH:5][CH:6]([OH:11])[C:7]([O:9][CH3:10])=[O:8])(=[O:4])[CH:2]=[CH2:3].CO.[CH3:14]OC.C1(C=CC(O)=CC=1)O.C(N(CC(O)=O)CC(O)=O)CN(CC(O)=O)CC(O)=O>>[CH3:14][O:11][CH:6]([NH:5][C:1](=[O:4])[CH:2]=[CH2:3])[C:7]([O:9][CH3:10])=[O:8]

참가 물질

6

반응물 5

HCID 785HydroquinoneHCID 887MethanolHCID 6049Ethylenediaminetetraacetic AcidHCID 8254Dimethyl EtherHCID 157058Methyl 2-hydroxy-2-(1-oxo-2-propenylamino)acetate

생성물 1

HCID 156893Methyl acrylamidoglycolate methyl ether수율 85%

실험 절차

Methyl acrylamidoglycolate, as prepared in Example I, in the amount of 100 parts (0.63 mole) is combined with 200 parts of methanol (6.3 moles), 0.10 parts of the methyl ether of hydroquinone and 0.005 part of ethylene-diamine tetraacetic acid and 5.0 parts of a 40% aqueous solution of paratoluenesulfonic acid is added as catalyst. The reaction mixture is heated for 4 hours at reflux temperature and then cooled and filtered. Vacuum stripping of the methanol results in crystallization of the product. An 85% yield of methyl acrylamidoglycolate methyl ether is obtained.

후처리

  1. additionis added as catalyst
  2. temperatureThe reaction mixture is heated for 4 hours
  3. temperatureat reflux temperature
  4. temperaturecooled
  5. filtrationfiltered
  6. customVacuum stripping of the methanol results in crystallization of the product

출처 및 근거

ORD 기록
ord-63962f70461247b29c2f55b66540cc30
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04760168

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