3-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl ester → Isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydrothien-3-yl]ureido}-benzoate

HRID 845977노트

반응식

HRID 845977 반응식
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH2:18])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].O=[C:20]1[CH:24]([C:25]([O:27][CH3:28])=[O:26])[CH2:23][S:22][CH2:21]1>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:20]2[CH2:21][S:22][CH2:23][C:24]=2[C:25]([O:27][CH3:28])=[O:26])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

참가 물질

3

반응물 2

HCID 984243-Thiophenecarboxylic acid, tetrahydro-4-oxo-, methyl esterHCID 20130672Isopropyl 2-chloro-4-fluoro-5-ureidobenzoate

생성물 1

HCID 20130628Isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydrothien-3-yl]ureido}-benzoate

실험 절차

using isopropyl 2-chloro-4-fluoro-5-ureidobenzoate and methyl 3-oxotetrahydrothiophene-4-carboxylate there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[4-(methoxycarbonyl)-2,5-dihydro-thien-3-yl]ureido}-benzoate,

출처 및 근거

ORD 기록
ord-cdabe622fae447bbbfdbd0f5a97f8b30
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04760163

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