Piperazine → 1-[6-(Trifluoromethyl)pyridin-2-yl]piperazine
반응식
Cl[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([C:8]([F:11])([F:10])[F:9])[N:3]=1.[NH:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>C(#N)C>[F:9][C:8]([F:11])([F:10])[C:4]1[N:3]=[C:2]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:7]=[CH:6][CH:5]=1참가 물질
4
실험 절차
54.4 g of 2-chloro-6-trifluoromethyl pyridine are dissolved into a mixture of 350 ml of acetonitrile and 77.4 g of anhydrous piperazine. The mixture is filtered and washed with acetonitrile. The solvent is evaporated. The residue is taken up with dichloromethane and washed with water. The solution is dried over magnesium sulfate. The solvent is evaporated and the residue distilled, to obtain 56.4 g of 1-[6-(trifluoromethyl)-2-pyridinyl]piperazine (81.4% yield), having a boiling point of 103° C. at 0.05 mm Hg.
후처리
- filtrationThe mixture is filtered
- washwashed with acetonitrile
- customThe solvent is evaporated
- washwashed with water
- dry with materialThe solution is dried over magnesium sulfate
- customThe solvent is evaporated
- distillationthe residue distilled
출처 및 근거
- ORD 기록
- ord-0748859c41e849c7bd152afeb1ec080d
- 출처 데이터셋
- uspto-grants-1992_08
- 특허 번호
- US05135931
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