Sulfuric Acid → HCID 14698595, 화합물

HRID 846208노트

반응식

HRID 846208 반응식
[C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])#[N:2].S(=O)(=O)(O)[OH:24]>>[NH2:2][C:1]([C:3]([C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:22])[C:14]2[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=2)=[CH:8][CH:7]=1)([CH3:5])[CH3:4])=[O:24]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 14698596HCID 14698596, 화합물

생성물 1

HCID 14698595HCID 14698595, 화합물

실험 절차

5 g. N-[4-(1-Cyano-1-methylethyl)-phenyl]-4-methoxybenzamide (Example 27) are stirred for 20 hours at ambient temperature in 100 ml. concentrated sulphuric acid, poured on to ice, the precipitate is filtered off with suction, dissolved in hot glacial acetic acid, water added thereto until the commencement of turbidity and then left to cool. There are obtained 2.2 g. (42% of theory) of the title compound in the form of colourless crystals; m.p. 234°-235° C.

후처리

  1. filtrationthe precipitate is filtered off with suction
  2. dissolutiondissolved in hot glacial acetic acid
  3. additionwater added
  4. waituntil the commencement of turbidity and then left
  5. temperatureto cool
  6. customThere are obtained 2.2 g

출처 및 근거

ORD 기록
ord-f5e27edd7b3046fc8b07123cd5c28b19
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05135949

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