2,3-Difluoro-6-nitro-(2-p-toluenesulfonyloxypropyl)oxybenzene → 2,3-Difluoro-6-amino-[(2-p-toluenesulfonyloxypropyl)oxy]benzene

HRID 846336노트

반응식

HRID 846336 반응식
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([N+:9]([O-])=O)[C:3]=1[O:12][CH2:13][CH:14]([O:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[CH3:15]>C(O)C.[Pd]>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([NH2:9])[C:3]=1[O:12][CH2:13][CH:14]([O:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=1)(=[O:19])=[O:18])[CH3:15]

참가 물질

4

반응물 1

HCID 146971942,3-Difluoro-6-nitro-(2-p-toluenesulfonyloxypropyl)oxybenzene

생성물 1

HCID 146971972,3-Difluoro-6-amino-[(2-p-toluenesulfonyloxypropyl)oxy]benzene

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To a solution of 2.32 g of the compound obtained in Example 8 in 50 ml of ethanol was added 1 g of 5% palladium on charcoal, and the catalytic reduction was carried out under atmospheric pressure at room temperature for about 1 hour. The catalyst was removed by filtration, and the solvent was removed under reduced pressure to yield the titled compound. This product was used in the following reaction without purification.

후처리

  1. customThe catalyst was removed by filtration
  2. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-2dc506dc92d441378a47592ee4bf8a1c
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05136059

반응 노트

불러오는 중…