Acetone Cyanohydrin → (3S)-3-hydroxy-3-phenylpropanenitrile
반응식
[CH2:1]1[O:9][C@@H:2]1[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.CC(C)(O)[C:12]#[N:13].C(N(CC)CC)C>O1CCCC1>[C:3]1([C@@H:2]([OH:9])[CH2:1][C:12]#[N:13])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1참가 물질
5
실험 절차
A mixture of 40.0 g of (R)-styrene oxide, 31.12 g of acetone cyanohydrin, 36.96 g of triethylamine, and 150 ml of tetrahydrofuran was heated at reflux for 18 hours. The reaction mixture was cooled, concentrated in vacuo, diluted with 200 ml of 2N potassium hydroxide, and extracted with diethyl ether. The ether extracts were combined, dried over magnesium sulfate, and concentrated in vacuo providing 34.3 g of the title intermediate.
후처리
- temperaturewas heated
- temperatureat reflux for 18 hours
- temperatureThe reaction mixture was cooled
- concentrationconcentrated in vacuo
- additiondiluted with 200 ml of 2N potassium hydroxide
- extractionextracted with diethyl ether
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-031d64a9ec0c47989fe335f90f58eb3c
- 출처 데이터셋
- uspto-grants-1992_08
- 특허 번호
- US05136078
반응 노트
불러오는 중…