Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2-Methoxyphenyl)piperazine → 3-[4-[1-(2-Methoxyphenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2-Methoxyphenyl)piperazine | HCID 1346 | — |
| 반응물 | Sodium Iodide | HCID 5238 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3-(4-Bromobutyl)-2-methyl-4-thiazolidinone | HCID 10490993 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-[4-[1-(2-Methoxyphenyl)-4-piperazinyl]butyl]-2-Methyl-4-thiazolidinone | HCID 15662325 | — |
반응 단계
A suspension of 2-methyl-3-(4-bromobutyl)-4-thiazolidinone (3.0 g), 1-(2-methoxyphenyl)piperazine (2.3 g), anhydrous K2CO3 (3.5 g) and NaI (200 mg) in 100 ml of anhydrous CH3CN was heated to 80° under N2. After 4 hours no starting material remained as judged by TLC. The mixture was cooled to room temperature, filtered and concentrated in vauco. The residue was chromatographed on silica, using EtOAc as the eluent. This provided 2.18 g of product as a clear oil which solidified in vacuo (0.1 mmHg) overnight.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05136037 |
| 출처 데이터셋 | uspto-grants-1992_08 |
| ORD ID | ord-7225c03122df48dc911763a8e27c0482 |
| 출처 메모 | uspto-grants-1992_08 |