beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester → beta-Amino-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester

HRID 846466노트

반응식

HRID 846466 반응식
CC(C)(OC([NH:7][CH:8]([CH2:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[CH:9]([OH:16])[C:10]([O:12][CH:13]([CH3:15])[CH3:14])=[O:11])=O)C>C(Cl)Cl>[NH2:7][CH:8]([CH2:17][CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]1)[CH:9]([OH:16])[C:10]([O:12][CH:13]([CH3:14])[CH3:15])=[O:11]

참가 물질

3

반응물 1

HCID 15674228beta-[[(1,1-Dimethylethoxy)carbonyl]amino]-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester

생성물 1

HCID 3256856beta-Amino-alpha-hydroxycyclohexanebutanoic acid, 1-methylethyl ester수율 73%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxycyclohexanebutanoic acid, 1-methylethyl ester (mixture of [R-(R*,S*)] and [S-(R*,R*)]isomers) (Example F), 3.4 g (10 mmol), is dissolved in methylene chloride, cooled to 0° C. and hydrochloric acid gas is bubbled in for five minutes every 15 minutes for two hours. The solution is diluted with ethyl acetate (50 ml) washed with saturated sodium bicarbonate solution (100 ml) and then with saturated brine solution (100 ml). The organics are separated, dried over magnesium sulfate and evaporated to dryness in vacuo to give 1.75 g (73%) of the title compound as an oil.

후처리

  1. customhydrochloric acid gas is bubbled in for five minutes every 15 minutes for two hours
  2. additionThe solution is diluted with ethyl acetate (50 ml)
  3. washwashed with saturated sodium bicarbonate solution (100 ml)
  4. customThe organics are separated
  5. dry with materialdried over magnesium sulfate
  6. customevaporated to dryness in vacuo

출처 및 근거

ORD 기록
ord-c0c0271fc7a84572b584da7e38f4868b
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05135914

반응 노트

불러오는 중…