Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Bromine | HCID 24408 | — |
| 반응물 | 3',5'-Bis(tert-butyl)-4'-hydroxyacetophenone | HCID 616296 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Bromo-1-[3,5-di(tert-butyl)-4-hydroxyphenyl]ethan-1-one | HCID 616161 | — |
반응 단계
20.6 g (83 mmol) of 1-(3,5-di-tert.-butyl-4-hydroxy-phenyl)ethanone were dissolved in 50 ml of methylene chloride with stirring and heated to boiling, and 14.4 g (90 mmol) of bromine were added dropwise in the course of 15 minutes. The mixture was then heated under reflux for a further 2 hours and cooled, 50 ml of water were added, and the organic phase was separated and dried over sodium sulfate. After removing the solvent under reduced pressure, the solid residue was recrystallized from methylcyclohexane.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05137897 |
| 출처 데이터셋 | uspto-grants-1992_08 |
| ORD ID | ord-6d7d148d343648b0a8fd0c8b95b45100 |
| 출처 메모 | uspto-grants-1992_08 |