반응식
[CH3:1][O:2][C:3]1([O:8][CH3:9])[CH2:7][CH2:6][NH:5][CH2:4]1.Cl[C:11]1[CH:20]=[C:19]2[C:14]([C:15](=[O:27])[C:16]([C:24]([OH:26])=[O:25])=[CH:17][N:18]2[CH:21]2[CH2:23][CH2:22]2)=[CH:13][C:12]=1[F:28]>>[CH:21]1([N:18]2[C:19]3[C:14](=[CH:13][C:12]([F:28])=[C:11]([N:5]4[CH2:6][CH2:7][C:3]([O:8][CH3:9])([O:2][CH3:1])[CH2:4]4)[CH:20]=3)[C:15](=[O:27])[C:16]([C:24]([OH:26])=[O:25])=[CH:17]2)[CH2:22][CH2:23]1참가 물질
3
실험 절차
Following procedures similar to Step 5 of Example 1, a 0.186 g (1.4 mmol) sample of 3,3-dimethoxypyrrolidine, from Step 4 of Example 1, was reacted with 0.200 g (0.7 mmol) of 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (preparation described by K. Grohe, et al., DE 3142854, May, 1983) at 60° C. under N2 for 188 hours to yield the title compound, mp 224°-226° C.: MS (DCl) M/Z 377 (M+H); NMR d 1.42 (d, 1H), 1.63 (m, 2H), 3.75 (s, 3H), 3.99 (s, 3H), 4.02 (m, 1H), 4.26 (m, 2H), 4.40 (m, 2H), 7.46 (d, 1H, J=7.5 Hz), 8.13 (d, 1H, J=13.5 Hz), 9.19 (s, 1H). Analysis calculated for C19H21FN2O5 ·0.5 H2O: C, 59.21; H, 5.75; N, 7.27. Found: C, 59.70; H, 5.48; N, 7.13.
출처 및 근거
- ORD 기록
- ord-706139c1c76a41228b2b0f1650250d20
- 출처 데이터셋
- uspto-grants-1992_08
- 특허 번호
- US05137892
연결된 노트
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