Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl (ethoxymethylene)malonate → Diethyl [2,3,4-trifluoro[(1S)-2-hydroxy-1-methylethyl]anilino]methylenemalonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | (2S)-2-(2,3,4-Trifluoroanilino)propanol | HCID 11401466 | — |
| 촉매 | Tetrahexylammonium chloride | HCID 80021 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Diethyl [2,3,4-trifluoro[(1S)-2-hydroxy-1-methylethyl]anilino]methylenemalonate | HCID 11485652 | 84% |
반응 단계
The compound (300 mg) obtained in Example 51, diethyl ethoxymethylenemalonate (632 mg) and tetrahexylammonium chloride (57 mg) were dissolved in acetone (3 ml). After adding potassium carbonate (445 mg), the mixture was stirred at room temperature for 4.5 hours. After the completion of the reaction, the solvent was evaporated. Then the residue thus obtained was subjected to silica gel column chromatography to thereby give 338 mg (84%) of the title compound as a colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07087778B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-0fdce4243602453b99f4511ddffe2546 |
| 출처 메모 | uspto-grants-2006_08 |