Acetonitrile → Didodecyl P-[1-(N-Octadecyl-N-dodecyloxyamino)octadecyl]phosphonate

HRID 846843

반응식

HRID 846843 반응식
[CH:1](=[N+:19]([O-:38])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[CH2:39]([O:51][P:52]([O:66]CCCCCCCCCCCC)[O:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH3:65])[CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50].[CH2:79](I)[CH2:80][CH2:81][CH2:82][CH2:83][CH2:84][CH2:85][CH2:86][CH2:87][CH2:88][CH2:89][CH3:90].C(#N)C>C1(C)C=CC=CC=1>[CH2:1]([N:19]([CH:20]([P:52](=[O:66])([O:53][CH2:54][CH2:55][CH2:56][CH2:57][CH2:58][CH2:59][CH2:60][CH2:61][CH2:62][CH2:63][CH2:64][CH3:65])[O:51][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37])[O:38][CH2:90][CH2:89][CH2:88][CH2:87][CH2:86][CH2:85][CH2:84][CH2:83][CH2:82][CH2:81][CH2:80][CH3:79])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

참가 물질

6

반응물 4

HCID 6342AcetonitrileHCID 202821-IodododecaneHCID 76495Trilauryl phosphiteHCID 71340222N-Octadecyloctadecan-1-imine N-oxide

생성물 1

HCID 19883776Didodecyl P-[1-(N-Octadecyl-N-dodecyloxyamino)octadecyl]phosphonate수율 29%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
70 °C

실험 절차

Following the procedure of Example 7, the title compound is prepared from 2.5 g (4.6 mmol) of N-(1-octadecylidene)-octadecylamine N-oxide, 2.9 g (5.0 mmol) of tri-n-dodecylphosphite, 3.0 g (10 mmol) of n-dodecyl iodide, 20 ml of acetonitrile and 40 ml of toluene by heating at 70° C. for 24 hours. The residue is purified by flash chromatography (10:1 hexane:ethyl acetate eluent) to give 1.5 g (29% yield) of the title compound as a white, low melting wax.

후처리

  1. customThe residue is purified by flash chromatography (10:1 hexane:ethyl acetate eluent)

출처 및 근거

ORD 기록
ord-aac2045cc0d74fb3af58ec26691fc122
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05137951

연결된 노트

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