Piperazine → 2-Methyl-4-(piperazin-1-yl)pyrimidine

HRID 846844노트

반응식

HRID 846844 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[N:3]=1.[NH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1>O1CCCC1>[CH3:8][C:4]1[N:3]=[C:2]([N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:7]=[CH:6][N:5]=1

참가 물질

4

반응물 2

HCID 4837PiperazineHCID 4244474-Chloro-2-methylpyrimidine

생성물 1

HCID 148385552-Methyl-4-(piperazin-1-yl)pyrimidine

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

13 g of 4-chloro-2-methyl-pyrimidine were dissolved in 200 ml of tetrahydrofuran, and 17.5 g of piperazine were added. The reaction mixture was refluxed for 24 h. The precipitated piperazine hydrochloride was filtered off with suction and washed with tetrahydrofuran. Concentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine, which was reacted without further purification.

후처리

  1. temperatureThe reaction mixture was refluxed for 24 h
  2. filtrationThe precipitated piperazine hydrochloride was filtered off with suction
  3. washwashed with tetrahydrofuran
  4. customConcentration of the solution in vacuo resulted in 19 g of 2-methyl-4-piperazino-pyrimidine
  5. customwhich was reacted without further purification

출처 및 근거

ORD 기록
ord-1684b2b7aac043178849f16e01f9be81
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05138058

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