3,4-Difluorobenzoic acid → 1-(3,4-Difluorophenyl)ethan-1-one

반응식

[F:1][C:2]1[C:10]([F:11])=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([N+]([O-])=O)[CH:3]=1.F[C:16]1C=C(C=CC=1F)C(O)=O>>[CH3:16][C:6]([C:5]1[CH:4]=[CH:3][C:2]([F:1])=[C:10]([F:11])[CH:9]=1)=[O:8]

참가 물질

반응물 2

HCID 991663,4-Difluorobenzoic acid

HCID 42196304,5-Difluoro-2-nitrobenzoic acid

생성물 1

HCID 1230521-(3,4-Difluorophenyl)ethan-1-one

실험 절차

Briefly, the benzoyl ester derivatives of formula II are prepared by reacting 5-fluoro-4-halo-2-nitrobenzoic acid with a chlorinating agent, such as thionyl chloride or trichlorophosphorous, followed by reacting the acid chloride so formed with a dialkylmalonate. The 4,5-difluoro-2-nitrobenzoic acid starting material can be prepared by nitration in mixed acid of 3,4-difluorobenzoic acid, which is obtained by oxidation 3,4-difluoroacetophenone. The 4- chloro-5-fluoro-2-nitrobenzoic acid starting material can be obtained by the following process:

출처 및 근거

ORD 기록: ord-e410c75b2d4843988731bcdd374b5e1d
출처 데이터셋: uspto-grants-1992_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05138088

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