Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Morpholinopiperidine → N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Morpholinopiperidine | HCID 795724 | — |
| 반응물 | 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide | HCID 57900337 | — |
| 생성물 | N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide | HCID 44241964 | — |
반응 단계
Following Example 70 and General Procedure D, 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide 160bp and 4-(4-piperidinyl)morpholine were reacted to give 127bp. 1H NMR (400 MHz, CDCl3) δ 7.20 (m, 1 H), 7.05-7.10 (m, 2 H), 6.84-6.93 (m, 3 H), 6.74 (m, 1 H), 5.05 (s, 2 H), 4.00 (m, 4 H,), 3.63-3.68 (m, 3 H), 3.29-3.50 (m, 5 H), 3.18 (m, 2 H), 3.05 (m, 2H), 2.47 (m, 2 H), 2.21 (m, 2 H). LCMS (ESI) m/z: 526.1
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08846762B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-bb2a321cd09c4480bf826ee86c79f5cf |
| 출처 메모 | uspto-grants-2014_09 |