4-Morpholinopiperidine → N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide

HRID 84699

반응식

HRID 84699 반응식
Br[C:2]1[CH:11]=[CH:10][C:9]2[O:8][CH2:7][C:6]3[CH:12]=[C:13]([C:15]([N:17]([C:19]4[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=4[F:26])[CH3:18])=[O:16])[S:14][C:5]=3[C:4]=2[CH:3]=1.[NH:27]1[CH2:32][CH2:31][CH:30]([N:33]2[CH2:38][CH2:37][O:36][CH2:35][CH2:34]2)[CH2:29][CH2:28]1>>[F:26][C:20]1[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:19]=1[N:17]([CH3:18])[C:15]([C:13]1[S:14][C:5]2[C:4]3[CH:3]=[C:2]([N:27]4[CH2:32][CH2:31][CH:30]([N:33]5[CH2:38][CH2:37][O:36][CH2:35][CH2:34]5)[CH2:29][CH2:28]4)[CH:11]=[CH:10][C:9]=3[O:8][CH2:7][C:6]=2[CH:12]=1)=[O:16]

참가 물질

3

반응물 2

HCID 7957244-MorpholinopiperidineHCID 579003378-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide

생성물 1

HCID 44241964N-(2,4-difluorophenyl)-N-methyl-8-(4-morpholinopiperidine-1-yl)-4H-thieno[3,2-c]chromene-2-carboxamide

실험 절차

Following Example 70 and General Procedure D, 8-bromo-N-(2,4-difluorophenyl)-N-methyl-4H-thieno[3,2-c]chromene-2-carboxamide 160bp and 4-(4-piperidinyl)morpholine were reacted to give 127bp. 1H NMR (400 MHz, CDCl3) δ 7.20 (m, 1 H), 7.05-7.10 (m, 2 H), 6.84-6.93 (m, 3 H), 6.74 (m, 1 H), 5.05 (s, 2 H), 4.00 (m, 4 H,), 3.63-3.68 (m, 3 H), 3.29-3.50 (m, 5 H), 3.18 (m, 2 H), 3.05 (m, 2H), 2.47 (m, 2 H), 2.21 (m, 2 H). LCMS (ESI) m/z: 526.1

후처리

  1. customwere reacted
  2. customto give 127bp

출처 및 근거

ORD 기록
ord-bb2a321cd09c4480bf826ee86c79f5cf
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08846762B2

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