2-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamine → 2-Cyanomethyl-3-hexadecyloxypropylamine

HRID 847015노트

반응식

HRID 847015 반응식
[N:1]([CH2:4][CH:5]([CH2:24][C:25]#[N:26])[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[N+]=[N-].C(OC(C)CC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)(=O)C1C=CC=CC=1.C(OC(NC(COC(=O)NCCCCCCCCCCCCCCCCCC)CN)=O)(C)(C)C>[Pd].CO>[C:25]([CH2:24][CH:5]([CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:4][NH2:1])#[N:26]

참가 물질

6

반응물 3

HCID 148350012-tert-Butoxycarbonylamino-3-octadecylcarbamoyloxypropylamineHCID 148350122-(2-Benzoyloxypropan-1-yl)-3-octadecylcarbamoyloxypropylamineHCID 198842081-Azido-2-cyanomethyl-3-hexadecyloxypropane

생성물 1

HCID 148350132-Cyanomethyl-3-hexadecyloxypropylamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A suspension of 3.00 g (23 mM) of 1-azido-2-cyanomethyl-3-hexadecyloxypropane V n1b and 300 mg of 10% palladium on charcoal in 100 ml of methanol is hydrogenated as described in (129) and the crude product of the titled compound IV n1 is obtained.

후처리

  1. customis obtained

출처 및 근거

ORD 기록
ord-3b6c824d548a4842877ca522fc6c3286
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05138067

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