Potassium Carbonate → Methyl 2-hydroxy-3-methylbutanoate

HRID 847116노트

반응식

HRID 847116 반응식
[CH3:1][C:2]1[CH:7]=C(C)N=C(S(C)(=O)=O)N=1.C(=O)([O-])[O-:14].[K+].[K+].[C:19]([O:22][CH2:23]C)(=[O:21])[CH3:20].CCCCCC>CC(C)=O>[OH:14][CH:20]([CH:2]([CH3:7])[CH3:1])[C:19]([O:22][CH3:23])=[O:21]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 27723824,6-Dimethyl-2-methylsulfonylpyrimidineHCID 21226206Ethyl acetate hexane

생성물 1

HCID 552631Methyl 2-hydroxy-3-methylbutanoate수율 42%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

1.5g of the product of (b) and 2.llg (0.011 moles) of 4,6-dimethyl-2-methanesulphonyl pyrimidine were dissolved in 20ml acetone. 1.6g of potassium carbonate were added and the reaction mixture refluxed for 4 hours. Following thin layer chromatography to establish that the reaction had reached completion, the mixture was evaporated to dryness and 10ml water added. Solvent extraction using chloroform followed and the chloroform extracts were dried over anhydrous sodium sulphate and the solvent evaporated off. The oil resulting was subjected to flash column chromatography using ethyl acetate: hexane (1:1) as eluant to yield 1.1g (yield 42%) of the title compound as a colourless oil.

후처리

  1. temperaturethe reaction mixture refluxed for 4 hours
  2. customthe mixture was evaporated to dryness and 10ml water
  3. additionadded
  4. extractionSolvent extraction
  5. dry with materialthe chloroform extracts were dried over anhydrous sodium sulphate
  6. customthe solvent evaporated off
  7. customThe oil resulting

출처 및 근거

ORD 기록
ord-cf79931c56a949f79b58fb9cfb194278
출처 데이터셋
uspto-grants-1992_08
특허 번호
US05139563

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