Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl bromoacetate → Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl bromoacetate | HCID 7748 | — |
| 반응물 | 4,6-Dimethylpyrimidin-2-ol | HCID 9508 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Ethyl 2-(4,6-dimethylpyrimidin-2-yl)oxyacetate | HCID 3410252 | 26.8% |
반응 단계
2-Hydroxy-4,6-dimethyl pyrimidine (10g, 0.08 mol) was dissolved in 150ml of dimethylformamide. Ethyl bromoacetate (13.5g, 0.08 mol) was added and also, subsequently, 11.lg of potassium carbonate. The reaction mixture was refluxed overnight. A precipitate had formed which was filtered off and the solvent was then evaporated off from the filtrate to form a crude oily product. Following purification by flash chromatography, 4.5g of the title product were obtained in the form of a red oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05139563 |
| 출처 데이터셋 | uspto-grants-1992_08 |
| ORD ID | ord-83d2bb0b404543c793d87e333bd2852c |
| 출처 메모 | uspto-grants-1992_08 |